Dimerization of Phospho IRF3 or phospho IRF7

Stable Identifier
R-HSA-1028821
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dimerization of Phospho IRF3 or phospho IRF7
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Phosphorylation of these transcription factors IRF3 and IRF7 results in a conformational change that allows their dimerization to form homo- or hetero dimers. Each of the three different combinations of dimers (IRF3:IRF3, IRF7:IRF7 and IRF3:IRF7) may selectively effect the transcription of IFN-alpha gene subfamilies and IFN-beta genes.
Literature References
PubMed ID Title Journal Year
12604599 Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators

Yang, H, Wathelet, MG, Ma, G, Lin, CH, Baffi, MO

J Biol Chem 2003
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Orthologous Events
Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)
Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)
Dimerization of Phospho IRF3 or phospho IRF7 (Rattus norvegicus)
Dimerization of Phospho IRF3 or phospho IRF7 (Sus scrofa)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-11-18)
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