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p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
Stable Identifier
R-HSA-1028815
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)
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IRF3:CBP/p300 complex binds specifically to IFN-beta promoter region and induces IFN-beta mRNA expression.
Literature References
PubMed ID
Title
Journal
Year
9541017
Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
Sato, M
,
Hata, N
,
Oda, E
,
Taniguchi, T
,
Tanaka, N
FEBS Lett
1998
Participants
Input
IFNB1 gene [nucleoplasm]
(Homo sapiens)
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 [nucleoplasm]
(Homo sapiens)
Output
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300:Promotor region of interferon beta [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TRAF3-dependent IRF activation pathway (Homo sapiens)
Authored
Garapati, P V (2010-08-02)
Reviewed
Akira, S (2010-10-30)
Kawai, T (2010-10-30)
Created
Garapati, P V (2010-11-18)
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