Reactome | ST8SIA6 [Golgi membrane]

ST8SIA6 [Golgi membrane]

Stable Identifier

R-HSA-1022137

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-2,8-sialyltransferase 8F, SIA8F_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)
        
        ST8SIA1-6 [Golgi membrane] (Homo sapiens)
        
        ST8SIA6 [Golgi membrane] (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        N-Glycan antennae elongation (Homo sapiens)
        
        ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)
        
        ST8SIA2,3,6 [Golgi membrane] (Homo sapiens)
        
        ST8SIA6 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61647 ST8SIA6

Gene Names

ST8SIA6, SIAT8F

Chain

chain:1-398

Reference Genes

BioGPS Gene:338596 ST8SIA6

COSMIC (genes):ST8SIA6 ST8SIA6

CTD Gene:338596 ST8SIA6

dbSNP Gene:338596 ST8SIA6

ENSEMBL:ENSG00000148488 ST8SIA6

ENSEMBL_homo_sapiens_GENE:ENSG00000148488.17 ST8SIA6

HGNC:23317 ST8SIA6

KEGG Gene (Homo sapiens):338596 ST8SIA6

Monarch:338596 ST8SIA6

NCBI Gene:338596 ST8SIA6

OMIM:610139 ST8SIA6

UCSC:P61647 ST8SIA6

Reference Transcript

RefSeq:NM_001004470.2 ST8SIA6

Other Identifiers

11738094_a_at

16712277

3279910

3279912

3279914

3279916

3279917

3279918

3279919

3279921

3279937

3279943

3279954

3279955

3279957

338596

61053_r_at

7932407

88296_at

A_32_P599

A_33_P3366758

A_33_P3403963

GE471739

GE762426

GO:0000139

GO:0001574

GO:0001835

GO:0003824

GO:0003828

GO:0005794

GO:0005975

GO:0006486

GO:0006491

GO:0006493

GO:0006629

GO:0008373

GO:0009100

GO:0009247

GO:0009311

GO:0016020

GO:0016051

GO:0016740

GO:0016757

GO:0036211

GO:0043226

GO:0048856

GO:1901135

HMNXSV003009660

HMNXSV003011484

ILMN_1698508

PH_hs_0008376

PH_hs_0026065

TC10001074.hg

Participates

as a member of

ST8SIA2,3,6 [Golgi membrane] (Homo sapiens)

as a candidate of

ST8SIA1-6 [Golgi membrane] (Homo sapiens)

Inferred To

ST8SIA6 [Golgi membrane] (Canis familiaris)

ST8SIA6 [Golgi membrane] (Gallus gallus)

ST8SIA6 [Golgi membrane] (Mus musculus)

ST8SIA6 [Golgi membrane] (Rattus norvegicus)

ST8SIA6 [Golgi membrane] (Sus scrofa)

st8sia6 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001004470.1

OpenTargets

ENSG00000148488

HPA

ENSG00000148488-ST8SIA6

GeneCards

P61647

Ensembl

ENSP00000366827, ENSG00000148488, ENST00000377602

PRO

P61647

Pharos - Targets

P61647

HMDB Protein

HMDBP13569

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