ISGF3 binds the ISRE promoter elements in IFN-stimulated genes

Stable Identifier
R-HSA-1015699
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ISGF3 binds the ISRE promoter elements in IFN-stimulated genes
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Effects of IFNs result from induction of a subset of genes, called IFN stimulated genes (ISGs). These ISGs are mainly implicated in anti-viral, anti-angiogenic, immunomodulatory, cell cycle inhibitory effects and apoptotic functions. All IFNA/B-stimulated genes have a conserved region of about 15bp in their promoter called the Interferon Stimulation Response Element (ISRE). The transcription factor ISGF3 binds to this ISRE and induce the transcription of these genes by IFN.

Literature References
PubMed ID Title Journal Year
18575461 Interferon-inducible antiviral effectors

Williams, BR, Sadler, AJ

Nat Rev Immunol 2008
12766484 Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis

Liu, YF, Lindner, DJ, Borden, EC, Silverman, RH, Chawla-Sarkar, M, Williams, BR, Sen, GC

Apoptosis 2003
7540766 Transcription factors in interferon signaling

David, M

Pharmacol Ther 1995
9861020 Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

Silverman, RH, Williams, BR, Der, SD, Zhou, A

Proc Natl Acad Sci U S A 1998
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Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-11-15)
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