Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HSPG2(22-4391) [extracellular region]
Stable Identifier
R-HSA-1011570
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
HSPG2, Perlecan, Basement membrane-specific heparan sulfate proteoglycan core protein
Locations in the PathwayBrowser for interactor UniProt:P05230 FGF1
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
ECM proteoglycans (Homo sapiens)
HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
Laminin interactions (Homo sapiens)
Laminins bind HSPG2 (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
Laminins:Nidogens binds HSPG2 (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
HSPG2(22-4391) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98160 HSPG2
Gene Names
HSPG2
Chain
signal peptide:1-21, chain:22-4391, chain:3687-4391, chain:4197-4391
Reference Genes
COSMIC (genes):HSPG2 HSPG2
dbSNP Gene:3339 HSPG2
ENSEMBL:ENSG00000142798 HSPG2
Participates
as a component of
HSPG2:Dystroglycan [plasma membrane] (Homo sapiens)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
Laminins with gamma-1, gamma-3:Nidogens:HSPG2 [extracellular region] (Homo sapiens)
Laminins with alpha-1, -2 or -5:HSPG2(22-4391) [extracellular region] (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
as an input of
HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
Degradation of HSPG2 by Mmp13 and Ctss (Homo sapiens)
HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)
HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)
HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)
HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)
Laminins:Nidogens binds HSPG2 (Homo sapiens)
Laminins bind HSPG2 (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
as a member of
AGRN, HSPG2 [extracellular region] (Homo sapiens)
Other forms of this molecule
HSPG2(22-4196) [extracellular region]
HS(4)-HSPG2 [plasma membrane]
HS(6)-HSPG2 [plasma membrane]
HS(2)-HSPG2 [plasma membrane]
HS(1)-HSPG2 [plasma membrane]
HS(3)-HSPG2 [plasma membrane]
HS(5)-HSPG2 [plasma membrane]
HSPG2(3687-4391) [extracellular region]
XylS-HSPG2(22-4391) [Golgi lumen]
Gal-Xyl-HSPG2 [Golgi lumen]
HSPG2(22-4391) [Golgi lumen]
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
HS(3)-HSPG2 [Golgi lumen]
HS(4)-HSPG2 [Golgi lumen]
HS(2)-HSPG2 [Golgi lumen]
HS(1)-HSPG2 [Golgi lumen]
Heparan(4)-HSPG2 [Golgi lumen]
Heparan(3)-HSPG2 [Golgi lumen]
Heparan(2)-HSPG2 [Golgi lumen]
Heparan(1)-HSPG2 [Golgi lumen]
Heparan-HSPG2 [Golgi lumen]
HS(5)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [lysosomal lumen]
HSPG2(22-4391) [lysosomal lumen]
Heparan sulfate-HSPG2 [extracellular region]
HSPG2(?-4391) [extracellular region]
HSPG2(22-?) [extracellular region]
HSPG2(4197-4391) [extracellular region]
Inferred To
DIP-epsilon [extracellular region]
(Drosophila melanogaster)
HSPG2(22-4391) [extracellular region]
(Caenorhabditis elegans)
DIP-kappa [extracellular region]
(Drosophila melanogaster)
DIP-zeta [extracellular region]
(Drosophila melanogaster)
DIP-alpha [extracellular region]
(Drosophila melanogaster)
Lac [extracellular region]
(Drosophila melanogaster)
CT35363 [extracellular region]
(Drosophila melanogaster)
rig-5 [extracellular region]
(Caenorhabditis elegans)
DIP-eta [extracellular region]
(Drosophila melanogaster)
fipi [extracellular region]
(Drosophila melanogaster)
CT35293 [extracellular region]
(Drosophila melanogaster)
DIP-delta [extracellular region]
(Drosophila melanogaster)
DIP-gamma [extracellular region]
(Drosophila melanogaster)
DIP-beta [extracellular region]
(Drosophila melanogaster)
DIP-theta [extracellular region]
(Drosophila melanogaster)
DIP-lambda [extracellular region]
(Drosophila melanogaster)
Homologues of HSPG2(22-4391) [extracellular region]
(Caenorhabditis elegans)
Homologues of HSPG2(22-4391) [extracellular region]
(Drosophila melanogaster)
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.719
5
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.564
3
ChEBI:28304 HEPARIN
0.564
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.53
3
UniProt:Q9H9D4 ZN408
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text