Reactome | VPU (P05919) [endoplasmic reticulum membrane]

VPU (P05919) [endoplasmic reticulum membrane]

Stable Identifier

R-HIV-180550

Type

Protein [EntityWithAccessionedSequence]

Species

Human immunodeficiency virus 1

Compartment

endoplasmic reticulum membrane

GO Cellular Component

host cell endoplasmic reticulum membrane (0044167)

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Locations in the PathwayBrowser for interactor UniProt:Q9NVI7 ATD3A

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External Reference Information

External Reference

UniProt:P05919 vpu

Gene Names

vpu

Chain

chain:1-82

Reference Genes

BioGPS Gene:155945 vpu

KEGG Gene (Hepatitis C Virus):155945 vpu

Monarch:155945 vpu

NCBI Gene:155945 vpu

Reference Transcript

RefSeq:NC_001802.1 vpu

Participates

as an output of

Synthesis of VPU protein (Homo sapiens)

as an input of

as a component of

Other forms of this molecule

VPU (P05919) protein [cytosol]

VPU (P05919) protein [extracellular region]

VPU (P05919) protein [nucleoplasm]

VPU (P05919) [Golgi membrane]

VPU (P05919) [plasma membrane]

Cross References

RefSeq

NP_057855.1

PDB

2N29

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.597	3
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.597	4
UniProt:P01730 CD4	4	CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [early endosome] (R-HSA-182147) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.524	3
UniProt:P13598 ICAM2	1	ICAM2 [plasma membrane] (R-HSA-197852)	0.462	2
UniProt:Q9NQC3 RTN4	1	RTN4 [plasma membrane] (R-HSA-194556)	0.462	4
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.462	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.462	2
UniProt:Q9GZT3 SLIRP	1	SLIRP [mitochondrial matrix] (R-HSA-9837039)	0.462	4
UniProt:Q99653 CHP1	1	p-CHP1 [plasma membrane] (R-HSA-5333747)	0.462	2
UniProt:P42695 NCAPD3	3	p-T1415,S1419-NCAPD3 [nucleoplasm] (R-HSA-2294594) p-T1415-NCAPD3 [nucleoplasm] (R-HSA-2294587) NCAPD3 [nucleoplasm] (R-HSA-1629790)	0.462	2
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.462	4
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.462	2
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.462	2
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.462	4
UniProt:O14828 SCAM3			0.462	4
UniProt:Q9UHQ9 CYB5R1	3	CYB5R1 [plasma membrane] (R-HSA-8848888) CYB5R1 [platelet alpha granule membrane] (R-HSA-8848891) CYB5R1 [endoplasmic reticulum membrane] (R-HSA-6806847)	0.462	4
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.462	4
UniProt:P78357 CNTNAP1	1	CNTNAP1 [plasma membrane] (R-HSA-373626)	0.462	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.462	2
UniProt:Q9NVI7 ATD3A			0.462	4
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.462	2
UniProt:Q9HAV4 XPO5	2	XPO5 [cytosol] (R-HSA-847719) XPO5 [nucleoplasm] (R-HSA-847721)	0.462	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.462	2
UniProt:Q96P70 IPO9			0.462	4
UniProt:Q96F15 GIMA5			0.462	2
UniProt:P26038 MSN	4	MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005)	0.462	2
UniProt:P48047 ATP5PO	1	ATP5PO [mitochondrial inner membrane] (R-HSA-164533)	0.462	2
UniProt:Q86XR8 CEP57	1	CEP57 [cytosol] (R-HSA-380271)	0.462	2
UniProt:P30049 ATP5F1D	1	ATP5F1D [mitochondrial matrix] (R-HSA-164574)	0.462	2
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.462	2
UniProt:Q53GQ0 HSD17B12	1	HSD17B12 [endoplasmic reticulum membrane] (R-HSA-548766)	0.462	2
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.462	2
UniProt:Q9Y6D6 BIG1			0.462	2
UniProt:Q9Y6D5 ARFGEF2	1	ARFGEF2 [cytosol] (R-HSA-391301)	0.462	2
UniProt:O95197 RTN3	1	RTN3 [plasma membrane] (R-HSA-8849907)	0.462	4
UniProt:P18859 ATP5PF	1	ATP5PF [mitochondrial inner membrane] (R-HSA-164532)	0.462	4
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.462	4
UniProt:Q5T9A4 ATAD3B	3	ATAD3B [ficolin-1-rich granule membrane] (R-HSA-6801277) ATAD3B [plasma membrane] (R-HSA-6806518) ATAD3B [secretory granule membrane] (R-HSA-6801313)	0.462	4
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.462	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.462	4
UniProt:Q86T03 TMEM55B	2	TMEM55B [late endosome membrane] (R-HSA-6810395) TMEM55B [nucleoplasm] (R-HSA-6810405)	0.462	4
UniProt:Q9UBB4 ATX10			0.462	4
UniProt:P20020 ATP2B1	1	ATP2B1 [plasma membrane] (R-HSA-418301)	0.462	2

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