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phospho-p-IRAK2 [endosome membrane]
Stable Identifier
R-GGA-975187
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
endosome membrane
Synonyms
F1N826
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF(TICAM1)-mediated TLR4 signaling (Gallus gallus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Gallus gallus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Gallus gallus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Gallus gallus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Gallus gallus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Gallus gallus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Gallus gallus)
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane] (Gallus gallus)
phospho-p-IRAK2 [endosome membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1N826
Reference Genes
ENSEMBL:ENSGALG00000008407
Other Identifiers
416118
AADN04000009
ENSGALG00000008407
ENSGALP00000035437
ENSGALT00000036214
EntrezGene:416118
EntrezGene:IRAK2
EntrezGene:IRAK2-201
Gga.7865.1.S1_at
GgaAffx.5299.1.S1_at
GgaAffx.5299.1.S1_s_at
GO:0001959
GO:0002376
GO:0002755
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0007165
GO:0007249
GO:0008150
GO:0009058
GO:0016301
GO:0019221
GO:0034641
GO:0035556
GO:0043167
GO:0043226
GO:0051092
GO:0070498
GT_A_87_P035554
GT_A_87_P074346
IPR000488
IPR000719
IPR011009
IPR011029
IPR033611
IRAK2
NM_001030605
NP_001025776
PF00069
PF00531
UPI0002C876F9
Participant Of
hasComponent
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane]
hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane]
p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]
Other forms of this molecule
IRAK2 [endosome membrane]
IRAK2 [cytosol]
phospho-p-IRAK2 [plasma membrane]
phospho-p-IRAK2 [cytosol]
Inferred From
p-IRAK2 [endosome membrane] (Homo sapiens)
hp-IRAK1/p-IRAK2 [endosome membrane] (Homo sapiens)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
PRO
F1N826
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