Reactome | EPGN [clathrin-coated endocytic vesicle membrane]

EPGN [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-GGA-9628815

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

EPGN(23-154), Q5EG71

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPGN [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5EG71

Gene Names

EPGN

Reference Genes

BioGPS Gene:497270 EPGN

ENSEMBL:ENSGALG00000010859

KEGG Gene (Gallus gallus):497270 EPGN

Monarch:497270 EPGN

NCBI Gene:497270 EPGN

Reference Transcript

RefSeq:NM_001012404.1 EPGN

Other Identifiers

497270

GO:0000165

GO:0000187

GO:0000278

GO:0001525

GO:0003674

GO:0005154

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005887

GO:0006464

GO:0007049

GO:0007165

GO:0007173

GO:0008083

GO:0008150

GO:0008283

GO:0008284

GO:0016020

GO:0016021

GO:0043406

GO:0045741

GO:0045840

GO:0048646

GO:0048856

GO:0050679

GO:0140014

GT_A_87_P035027

GgaAffx.6863.1.S1_at

Participates

as a member of

EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Other forms of this molecule

EPGN [extracellular region]

Inferred From

EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001012404.1

OpenTargets

ENSG00000182585

Ensembl

ENSGALG00000010859, ENSGALP00000017636, ENSGALT00000017657

PRO

Q5EG71

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