Reactome | TUBA3E [cytosol]

TUBA3E [cytosol]

Stable Identifier

R-GGA-9617120

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

TUBA3C, F1NWX0

Locations in the PathwayBrowser

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Autophagy (Gallus gallus)

- Macroautophagy (Gallus gallus)
  - Selective autophagy (Gallus gallus)
    - Aggrephagy (Gallus gallus)
      - PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Gallus gallus)
        
        PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)

Cell Cycle (Gallus gallus)

- Cell Cycle, Mitotic (Gallus gallus)
  - M Phase (Gallus gallus)
    - Mitotic Metaphase and Anaphase (Gallus gallus)
      - Mitotic Anaphase (Gallus gallus)
        
        Separation of Sister Chromatids (Gallus gallus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
    - Mitotic Prometaphase (Gallus gallus)
      - EML4 and NUDC in mitotic spindle formation (Gallus gallus)
        
        EML4 recruits NUDC to mitotic spindle (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
      - Resolution of Sister Chromatid Cohesion (Gallus gallus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        Kinetochore assembly (Gallus gallus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)

Cellular responses to stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Gallus gallus)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)
      - Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)

Hemostasis (Gallus gallus)

- Factors involved in megakaryocyte development and platelet production (Gallus gallus)
  - Kinesins (Gallus gallus)
    - Kinesins move along microtubules consuming ATP (Gallus gallus)
      - Kinesins:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Asparagine N-linked glycosylation (Gallus gallus)
    - Transport to the Golgi and subsequent modification (Gallus gallus)
      - ER to Golgi Anterograde Transport (Gallus gallus)
        
        COPI-mediated anterograde transport (Gallus gallus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - ER to Golgi Anterograde Transport (Gallus gallus)
    - COPI-mediated anterograde transport (Gallus gallus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Gallus gallus)
    - Golgi-to-ER retrograde transport (Gallus gallus)
      - COPI-dependent Golgi-to-ER retrograde traffic (Gallus gallus)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Gallus gallus)
        
        Kinesins:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Gallus gallus)
        
        Kinesins:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)
        
        Kinesins:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Gallus gallus)
        
        Kinesins:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
      - COPI-independent Golgi-to-ER retrograde traffic (Gallus gallus)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Gallus gallus)
        
        Dynein:Dynactin:microtubule [cytosol] (Gallus gallus)
        
        Microtubule [cytosol] (Gallus gallus)
        
        Microtubule protofilament [cytosol] (Gallus gallus)
        
        alpha-beta tubulin dimer [cytosol] (Gallus gallus)
        
        alpha-tubulin:GTP [cytosol] (Gallus gallus)
        
        alpha-tubulin [cytosol] (Gallus gallus)
        
        TUBA3E [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NWX0

Gene Names

TUBA3E

Reference Genes

BioGPS Gene:425049 TUBA3E

ENSEMBL:ENSGALG00000006241

ENSEMBL:ENSGALG00010001134.1 TUBA3E

KEGG Gene (Gallus gallus):425049 TUBA3E

Monarch:425049 TUBA3E

NCBI Gene:425049 TUBA3E

Reference Transcript

RefSeq:XM_422851.5 TUBA3E

Other Identifiers

425049

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0005198

GO:0005200

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0016787

GO:0043226

GT_A_87_P078196

GT_A_87_P189608

GT_A_87_P191288

GT_A_87_P281908

GgaAffx.6598.1.S1_at

Participates

as a candidate of

alpha-tubulin [cytosol] (Gallus gallus)

Other forms of this molecule

TUBA3E [axonemal microtubule]

Inferred From

TUBA3C/3D [cytosol] (Homo sapiens)

TUBA3D [cytosol] (Homo sapiens)

TUBA3C [cytosol] (Homo sapiens)

TUBA3E [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_422851.1

OpenTargets

ENSG00000152086

Ensembl

ENSGALG00010001134, ENSGALP00010001121, ENSGALT00010002571

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