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phospho-STAT3 [cytosol]
Stable Identifier
R-GGA-914048
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-Y705-STAT3, Q6DV79
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-10 signaling (Gallus gallus)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimerizes (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-12 family signaling (Gallus gallus)
Interleukin-23 signaling (Gallus gallus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)
p-Y705-STAT3:p-Y693-STAT4 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)
p-Y705-STAT3:p-Y693-STAT4 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-27 signaling (Gallus gallus)
p-STAT1 binds p-STAT3 (Gallus gallus)
p-Y701-STAT1: p-Y-705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)
p-Y701-STAT1: p-Y-705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin-21 signaling (Gallus gallus)
IL21 receptor STAT phosphorylation (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-9 signaling (Gallus gallus)
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)
IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y649-STAT5 [plasma membrane] (Gallus gallus)
p-Y701-STAT1,p-Y705-STAT3,p-Y694-STAT5A,p-STAT5B [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)
IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y649-STAT5 [plasma membrane] (Gallus gallus)
p-Y701-STAT1,p-Y705-STAT3,p-Y694-STAT5A,p-STAT5B [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1,p-Y705-STAT3,p-Y694-STAT5A,p-STAT5B [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-20 family signaling (Gallus gallus)
IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)
IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimerizes (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)
IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-4 and Interleukin-13 signaling (Gallus gallus)
JAK1 phosphorylates STAT3,STAT6 (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
STAT1,STAT3,STAT6 phosphorylation (Gallus gallus)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y-STATs dimerize (Gallus gallus)
p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y-STATs dissociate (Gallus gallus)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y-STATs translocate to nucleus (Gallus gallus)
p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Interleukin-6 family signaling (Gallus gallus)
Interleukin-6 signaling (Gallus gallus)
Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)
p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1: p-Y-705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Phosphorylated STATs are released (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)
p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3 [cytosol] (Gallus gallus)
p-Y701-STAT1: p-Y-705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Serine phosphorylation of STATs (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by MET (Gallus gallus)
MET activates STAT3 (Gallus gallus)
MET phosphorylates STAT3 (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Dimerization of STATs (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Gallus gallus)
p-STAT dimer [cytosol] (Gallus gallus)
p-STATs [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Gallus gallus)
p-STATs [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Disassociation and translocation of STATs to the nucleus (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Gallus gallus)
p-STAT dimer [cytosol] (Gallus gallus)
p-STATs [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
Phosphorylation of STATs (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Gallus gallus)
p-STATs [cytosol] (Gallus gallus)
phospho-STAT3 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q6DV79
Gene Names
STAT3
Reference Genes
BioGPS Gene:420027 STAT3
ENSEMBL:ENSGALG00000003267
KEGG Gene (Gallus gallus):420027 STAT3
Monarch:420027 STAT3
NCBI Gene:420027 STAT3
Reference Transcript
RefSeq:XM_015299598.1 STAT3
RefSeq:XM_015299599.1 STAT3
RefSeq:NM_001030931.1 STAT3
Participates
as an output of
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Gallus gallus)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)
p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)
MET phosphorylates STAT3 (Gallus gallus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Gallus gallus)
as a component of
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
p-Y705-STAT3:p-Y693-STAT4 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
p-Y701-STAT1: p-Y-705-STAT3 [cytosol] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Gallus gallus)
p-Y705-STAT3 dimer [cytosol] (Gallus gallus)
as an input of
p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)
p-STAT1 binds p-STAT3 (Gallus gallus)
p-Y705-STAT3 dimerizes (Gallus gallus)
p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)
as a member of
p-Y701-STAT1, p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [cytosol] (Gallus gallus)
p-Y701-STAT1,p-Y705-STAT3,p-Y694-STAT5A,p-STAT5B [cytosol] (Gallus gallus)
p-Y701-STAT1, p-Y705-STAT3 [cytosol] (Gallus gallus)
p-STATs [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-STAT3 [nucleoplasm]
phospho-STAT3 [cytosol]
phospho-STAT3 [nucleoplasm]
phospho-STAT3 [nucleoplasm]
phospho-STAT3 [nucleoplasm]
phospho-STAT3 [cytosol]
phospho-STAT3 [cytosol]
STAT3 [cytosol]
phospho-STAT3 [nucleoplasm]
Inferred From
p-Y705-STAT3,p-Y641-STAT6 [cytosol]
(Homo sapiens)
p-Y705-STAT3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 705 (in Homo sapiens)
Coordinate
705
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001026102.1
,
XP_015155084.1
,
XP_015155085.1
OpenTargets
ENSG00000168610
PRO
Q6DV79
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