Reactome | IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane]

IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane]

Stable Identifier

R-GGA-912317

Type

Complex

Species

Gallus gallus

Compartment

plasma membrane

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-2 family signaling (Gallus gallus)
      - Interleukin receptor SHC signaling (Gallus gallus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC1 recruits SHIP (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
      - Interleukin receptor SHC signaling (Gallus gallus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC1 recruits SHIP (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
      - Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
      - SHP1 and SHP2 bind the common beta chain (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
      - SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)
      - Tyrosine kinases phosphorylate the receptor (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Gallus gallus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Gallus gallus)

Participates

as a member of

as a component of

Inferred From

IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)

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