Reactome | PACSIN3 [cytosol]

PACSIN3 [cytosol]

Stable Identifier

R-GGA-8868270

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

PACSIN3, A0A3Q2TZM7

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - BAR domain proteins recruit dynamin (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PACSIN dimers [cytosol] (Gallus gallus)
        
        PACSIN3 dimer [cytosol] (Gallus gallus)
        
        PACSIN3 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2TZM7

Gene Names

PACSIN3

Reference Genes

BioGPS Gene:423186 PACSIN3

ENSEMBL:ENSGALG00000008231

ENSEMBL:ENSGALG00010022819.1 PACSIN3

Monarch:423186 PACSIN3

NCBI Gene:423186 PACSIN3

Reference Transcript

RefSeq:XM_015287027.1 PACSIN3

Other Identifiers

423186

GO:0005515

GO:0005543

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007010

GO:0008092

GO:0008289

GO:0016192

GO:0019855

GO:0030100

GO:0030163

GO:0031410

GO:0042802

GO:0043226

GO:0045806

GO:0051044

GO:0051926

GO:0061024

GO:0097320

GO:0098772

GT_A_87_P021900

GT_A_87_P193523

GT_A_87_P263488

Gga.12120.1.S1_at

Participates

as a component of

PACSIN3 dimer [cytosol] (Gallus gallus)

Inferred From

PACSIN3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015142513.1

OpenTargets

ENSG00000165912

Ensembl

ENSGALT00010055539, ENSGALG00010022819, ENSGALP00010033650

Cite Us!