Reactome | EPN2 [cytosol]

EPN2 [cytosol]

Stable Identifier

R-GGA-8865828

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

EPN2, A0A3Q2UI02

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - BAR domain proteins recruit dynamin (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
        
        UNQLNs:UIM proteins [cytosol] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)
        
        EPN2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2UI02

Gene Names

EPN2

Reference Genes

BioGPS Gene:416524 EPN2

ENSEMBL:ENSGALG00000035919

ENSEMBL:ENSGALG00010017407.1 EPN2

Monarch:416524 EPN2

NCBI Gene:416524 EPN2

Reference Transcript

RefSeq:XM_015294187.1 EPN2

Other Identifiers

416524

GO:0005543

GO:0005737

GO:0005768

GO:0005886

GO:0006897

GO:0008289

GO:0016192

GO:0023052

GO:0030125

GO:0030276

GO:0030948

GO:0031410

GO:0043226

GO:0043231

GO:0045747

GO:0048856

GO:1903671

GT_A_87_P010824

GT_A_87_P052941

GT_A_87_P071441

GT_A_87_P122563

GT_A_87_P128513

GT_Sp_Chicken_CN233621_5578

GT_Xhyb_Chicken_CO761631_4402

Gga.16726.1.S1_at

Gga.16726.1.S1_s_at

GgaAffx.20180.1.S1_s_at

GgaAffx.26415.1.S1_at

Participates

as a member of

EPS15,EPN1,EPN2 [cytosol] (Gallus gallus)

Inferred From

EPN2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015149673.1

OpenTargets

ENSG00000072134

Ensembl

ENSGALP00010024594, ENSGALG00010017407, ENSGALT00010042015

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