Reactome | RPLP2 [cytosol]

RPLP2 [cytosol]

Stable Identifier

R-GGA-72400

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

RPLP2, A0A1D5PMT8

Locations in the PathwayBrowser

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Metabolism of RNA (Gallus gallus)

- Nonsense-Mediated Decay (NMD) (Gallus gallus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Gallus gallus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        RPLP2 [cytosol] (Gallus gallus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        RPLP2 [cytosol] (Gallus gallus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        RPLP2 [cytosol] (Gallus gallus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Gallus gallus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        RPLP2 [cytosol] (Gallus gallus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        RPLP2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PMT8

Gene Names

RPLP2

Reference Genes

BioGPS Gene:426492 RPLP2

ENSEMBL:ENSGALG00000034811

ENSEMBL:ENSGALG00010023115.1 RPLP2

KEGG Gene (Gallus gallus):426492 RPLP2

Monarch:426492 RPLP2

NCBI Gene:426492 RPLP2

Reference Transcript

RefSeq:XM_424134.5 RPLP2

Other Identifiers

426492

GO:0002181

GO:0002182

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006414

GO:0022625

GO:0043226

GO:1990904

GT_A_87_P084176

GT_A_87_P117548

GT_A_87_P291813

GT_Xhyb_Chicken_AW198289_28

Gga.9470.1.S1_a_at

Gga.9470.2.S1_at

Participates

as a component of

Inferred From

RPLP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_424134.1

OpenTargets

ENSG00000177600

Ensembl

ENSGALP00010034106, ENSGALG00010023115, ENSGALT00010056338

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