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What is Reactome ?
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PSMC1 [cytosol]
Stable Identifier
R-GGA-68768
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1NSP7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle Checkpoints (Gallus gallus)
G1/S DNA Damage Checkpoints (Gallus gallus)
p53-Dependent G1/S DNA damage checkpoint (Gallus gallus)
p53-Dependent G1 DNA Damage Response (Gallus gallus)
Stabilization of p53 (Gallus gallus)
Autodegradation of the E3 ubiquitin ligase COP1 (Gallus gallus)
Proteasome mediated degradation of COP1 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
p53-Independent G1/S DNA damage checkpoint (Gallus gallus)
p53-Independent DNA Damage Response (Gallus gallus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Gallus gallus)
Proteolytic degradation of ubiquitinated-Cdc25A (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Separation of Sister Chromatids (Gallus gallus)
Degradation of multiubiquitinated Securin (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Gallus gallus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Regulation of mitotic cell cycle (Gallus gallus)
APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Gallus gallus)
Degradation of multiubiquitinated cell cycle proteins (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
APC/C:Cdc20 mediated degradation of Securin (Gallus gallus)
Degradation of multiubiquitinated Securin (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Gallus gallus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Gallus gallus)
Degradation multiubiquitinated Cyclin A (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
S Phase (Gallus gallus)
Synthesis of DNA (Gallus gallus)
Switching of origins to a post-replicative state (Gallus gallus)
CDK-mediated phosphorylation and removal of Cdc6 (Gallus gallus)
Ubiquitinated Cdc6 is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Orc1 removal from chromatin (Gallus gallus)
Ubiquitinated Orc1 is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Ubiquitin-dependent degradation of Cyclin D (Gallus gallus)
Proteasome mediated degradation of Cyclin D1 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
KEAP1-NFE2L2 pathway (Gallus gallus)
26S proteasome degrades Ub-NFE2L2 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
ub UBXN7 is degraded by the 26S proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Cellular response to hypoxia (Gallus gallus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Proteasome proteolyzes ub-HIF-alpha (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
DNA Replication (Gallus gallus)
Synthesis of DNA (Gallus gallus)
Switching of origins to a post-replicative state (Gallus gallus)
CDK-mediated phosphorylation and removal of Cdc6 (Gallus gallus)
Ubiquitinated Cdc6 is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Orc1 removal from chromatin (Gallus gallus)
Ubiquitinated Orc1 is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX1 (Gallus gallus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Gallus gallus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing-Cross presentation (Gallus gallus)
Cross-presentation of soluble exogenous antigens (endosomes) (Gallus gallus)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
Proteasomal cleavage of substrate (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Downstream signaling events of B Cell Receptor (BCR) (Gallus gallus)
Activation of NF-kappaB in B cells (Gallus gallus)
Ubiquitinated IkB is degraded (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 signaling (Gallus gallus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
TNFR2 non-canonical NF-kB pathway (Gallus gallus)
26Sproteasome degrades K48polyUb-NIK (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Protesomal degradation of K48polyUb-TRAF3 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated NF-kB activation (Gallus gallus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of polyamines (Gallus gallus)
Regulation of ornithine decarboxylase (ODC) (Gallus gallus)
26S proteosome degrades ODC holoenzyme complex (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Metabolism of RNA (Gallus gallus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Gallus gallus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Gallus gallus)
AUF1:mRNA complex is destroyed (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Gallus gallus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)
Deglycosylation complex [endoplasmic reticulum membrane] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Deubiquitination (Gallus gallus)
UCH proteinases (Gallus gallus)
ADRM1 binds 26S proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
ADRM1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
ADRM1:26S proteaseome binds UCHL5 (Gallus gallus)
ADRM1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
ADRM1:26S proteasome:UCHL5 [cytosol] (Gallus gallus)
ADRM1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
ADRM1:26S proteaseome binds USP14 (Gallus gallus)
ADRM1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
ADRM1:26S proteasome:USP14 [cytosol] (Gallus gallus)
ADRM1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Neddylation (Gallus gallus)
26S proteasome degrades HIFalpha (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
26S proteasome degrades Ub-NFE2L2 (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
ub UBXN7 is degraded by the 26S proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Proteasome assembly (Gallus gallus)
Formation of the 19S regulatory particle precursor (Gallus gallus)
19S RP base precursor [cytosol] (Gallus gallus)
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
19S RP precursor [cytosol] (Gallus gallus)
19S RP base precursor [cytosol] (Gallus gallus)
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
PSMC2 binds PSMC1 (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
PSMD5 and PSMD2 bind PSMC2:PSMC1 (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
Proteasome degrades polyubiquitinated PTEN (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
Regulation of RAS by GAPs (Gallus gallus)
NF1 is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
MAPK6/MAPK4 signaling (Gallus gallus)
MAPK6 is degraded by the 26S proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Signaling by Hedgehog (Gallus gallus)
Hedgehog 'off' state (Gallus gallus)
Degradation of GLI1 by the proteasome (Gallus gallus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
GLI3 is processed to GLI3R by the proteasome (Gallus gallus)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Hedgehog 'on' state (Gallus gallus)
ub-GLI is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Hedgehog ligand biogenesis (Gallus gallus)
Hh C-terminal fragments are degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
PCP/CE pathway (Gallus gallus)
Asymmetric localization of PCP proteins (Gallus gallus)
PRICKLE1 is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Degradation of beta-catenin by the destruction complex (Gallus gallus)
Degradation of ubiquitinated beta catenin by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
TCF dependent signaling in response to WNT (Gallus gallus)
Degradation of AXIN (Gallus gallus)
Ub-RibC-AXIN is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Ubiquitinated AXIN is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Degradation of DVL (Gallus gallus)
Ubiquitinated DVL is degraded by the proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
misfolded CFTR is degraded by the 26S proteasome (Gallus gallus)
26S proteasome [cytosol] (Gallus gallus)
19S regulatory particle [cytosol] (Gallus gallus)
19S RP base [cytosol] (Gallus gallus)
PSMC2:PSMC1:PSMD2 [cytosol] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
PSMC1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NSP7
Reference Genes
ENSEMBL:ENSGALG00000010675
Participates
as an input of
PSMC2 binds PSMC1 (Gallus gallus)
as a component of
Deglycosylation complex [endoplasmic reticulum membrane] (Gallus gallus)
PSMC2:PSMC1 [cytosol] (Gallus gallus)
Other forms of this molecule
PSMC1 [nucleoplasm]
Inferred From
PSMC1 [cytosol]
(Homo sapiens)
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