Reactome | DNA2 [nucleoplasm]

DNA2 [nucleoplasm]

Stable Identifier

R-GGA-68465

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

Q5ZKG3

Locations in the PathwayBrowser

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DNA Repair (Gallus gallus)

- DNA Double-Strand Break Repair (Gallus gallus)
  - Homology Directed Repair (Gallus gallus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
      - HDR through Homologous Recombination (HRR) (Gallus gallus)
        
        D-loop extension by DNA polymerases (Gallus gallus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Homologous DNA Pairing and Strand Exchange (Gallus gallus)
        
        CX3 complex binds D-loop structures (Gallus gallus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Gallus gallus)
        
        BCDX2 complex stabilizes RAD51 filament (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Resolution of D-Loop Structures (Gallus gallus)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Gallus gallus)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Gallus gallus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Gallus gallus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Gallus gallus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
      - HDR through Single Strand Annealing (SSA) (Gallus gallus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Gallus gallus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
      - Processing of DNA double-strand break ends (Gallus gallus)
        
        ATR activation at DNA DSBs (Gallus gallus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        ATR phosphorylates RPA2 (Gallus gallus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Binding of ATR:ATRIP to RPA at resected DNA DSBs (Gallus gallus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Gallus gallus)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Gallus gallus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Gallus gallus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)
        
        DNA2:WRN [nucleoplasm] (Gallus gallus)
        
        DNA2 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5ZKG3

Reference Genes

BioGPS Gene:423688

ENSEMBL:ENSGALG00000004037

KEGG Gene (Gallus gallus):423688

Monarch:423688

NCBI Gene:423688

Reference Transcript

RefSeq:NM_001006497.1

Participates

as a component of

Inferred From

DNA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001006497.1

PRO

Q5ZKG3

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