Reactome | ANAPC16 [nucleoplasm]

ANAPC16 [nucleoplasm]

Stable Identifier

R-GGA-6805137

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

ANAPC16, E1BVD8

Locations in the PathwayBrowser

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Cell Cycle (Gallus gallus)

- Cell Cycle, Mitotic (Gallus gallus)
  - Regulation of mitotic cell cycle (Gallus gallus)
    - APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Gallus gallus)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
        
        Phosphorylation of the APC/C (Gallus gallus)
        
        Free APC/C phosphorylated by Plk1 (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Gallus gallus)
        
        Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
      - Regulation of APC/C activators between G1/S and early anaphase (Gallus gallus)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)

Cellular responses to external stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Cellular Senescence (Gallus gallus)
    - Senescence-Associated Secretory Phenotype (SASP) (Gallus gallus)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Gallus gallus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)
        
        ANAPC16 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1BVD8

Gene Names

ANAPC16

Reference Genes

BioGPS Gene:423708 ANAPC16

ENSEMBL:ENSGALG00000004410

Monarch:423708 ANAPC16

NCBI Gene:423708 ANAPC16

Reference Transcript

RefSeq:XM_421587.5 ANAPC16

Other Identifiers

423708

GO:0000776

GO:0005575

GO:0005622

GO:0005634

GO:0005680

GO:0005694

GO:0005737

GO:0005829

GO:0006464

GO:0008150

GO:0016567

GO:0032991

GO:0043226

GT_A_87_P195053

Gga.5352.1.S1_a_at

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Gallus gallus)

Other forms of this molecule

ANAPC16 [cytosol]

Inferred From

ANAPC16 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_421587.3

OpenTargets

ENSG00000166295

Ensembl

ENSGALG00000004410, ENSGALP00000007017, ENSGALT00000007029

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