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TRADD [cytosol]
Stable Identifier
R-GGA-66376
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1NNN7
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
Dimerization of procaspase-8 (Gallus gallus)
TNF-mediated dimerization of procaspase-8 (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
Regulation by c-FLIP (Gallus gallus)
Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
Regulated Necrosis (Gallus gallus)
RIPK1-mediated regulated necrosis (Gallus gallus)
Regulation of necroptotic cell death (Gallus gallus)
CASP8 activity is inhibited (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
DISC [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8 (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8 (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Gallus gallus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
ULK1 phosphorylates RIPK1 at S357 (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNFR1-induced NF-kappa-B signaling pathway (Gallus gallus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TNFR1-induced proapoptotic signaling (Gallus gallus)
TRADD:TRAF2:RIP1 binds FADD (Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Gallus gallus)
TRADD [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NNN7
Reference Genes
ENSEMBL:ENSGALG00000003195
UCSC:F1NNN7
Participates
as a component of
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Gallus gallus)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
Inferred From
TRADD [cytosol]
(Homo sapiens)
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