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Factor VIII precursor [endoplasmic reticulum lumen]
Stable Identifier
R-GGA-5689449
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
endoplasmic reticulum lumen
Synonyms
A0A1D5NW08
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Formation of Fibrin Clot (Clotting Cascade) (Gallus gallus)
Intrinsic Pathway of Fibrin Clot Formation (Gallus gallus)
FVIII is secreted (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Transport to the Golgi and subsequent modification (Gallus gallus)
ER to Golgi Anterograde Transport (Gallus gallus)
COPII-mediated vesicle transport (Gallus gallus)
Inner coat assembly and cargo binding (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Loss of SAR1B GTPase (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Vesicle budding (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Cargo concentration in the ER (Gallus gallus)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Inner coat assembly and cargo binding (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
ER to Golgi Anterograde Transport (Gallus gallus)
COPII-mediated vesicle transport (Gallus gallus)
Inner coat assembly and cargo binding (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Loss of SAR1B GTPase (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Vesicle budding (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Cargo concentration in the ER (Gallus gallus)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Inner coat assembly and cargo binding (Gallus gallus)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
COPII cargo:receptors [endoplasmic reticulum membrane] (Gallus gallus)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Gallus gallus)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
Factor VIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5NW08
Reference Genes
ENSEMBL:ENSGALG00000005077
Participates
as a member of
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Gallus gallus)
as an input of
FVIII is secreted (Gallus gallus)
Other forms of this molecule
Factor VIII precursor [extracellular region]
Coagulation factor VIII precursor [platelet alpha granule lumen]
OSulf-6Y-FVIII precursor [Golgi lumen]
Factor VIII precursor [Golgi lumen]
F8(373-581) [extracellular region]
F8(20-355) [extracellular region]
F8(582-640) [extracellular region]
F8(356-372) [extracellular region]
Factor VIII precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
Factor VIII precursor [COPII-coated ER to Golgi transport vesicle]
factor VIIIa A3 C1 C2 polypeptide [extracellular region]
factor VIIIa A2 polypeptide [extracellular region]
factor VIIIa A1 polypeptide [extracellular region]
factor VIIIa B A3 acidic polypeptide [extracellular region]
factor VIII light chain [extracellular region]
factor VIII heavy chain [extracellular region]
factor VIIIa A1 polypeptide [plasma membrane]
factor VIIIa A3 C1 C2 polypeptide [plasma membrane]
factor VIIIa A2 polypeptide [plasma membrane]
Inferred From
Factor VIII precursor [endoplasmic reticulum lumen]
(Homo sapiens)
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