Reactome | phospho-RAD52 [nucleoplasm]

phospho-RAD52 [nucleoplasm]

Stable Identifier

R-GGA-5686588

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

p-Y104-RAD52, A0A1D5NXF5

Locations in the PathwayBrowser

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DNA Repair (Gallus gallus)

- DNA Double-Strand Break Repair (Gallus gallus)
  - Homology Directed Repair (Gallus gallus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
      - HDR through Single Strand Annealing (SSA) (Gallus gallus)
        
        ABL1 phosphorylates RAD52 (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Gallus gallus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)
        
        phospho-RAD52 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5NXF5

Gene Names

RAD52

Reference Genes

BioGPS Gene:418152 RAD52

ENSEMBL:ENSGALG00000039171

ENSEMBL:ENSGALG00010012367.1 RAD52

Monarch:418152 RAD52

NCBI Gene:418152 RAD52

Reference Transcript

Other Identifiers

418152

GO:0000724

GO:0000730

GO:0005634

GO:0006281

GO:0006302

GO:0006310

GO:0006312

GO:0006974

GO:0043226

GO:0045002

GO:0065003

GT_A_87_P023534

Gga.885.1.S1_at

Participates

as a component of

p-Y104-RAD52 heptamer [nucleoplasm] (Gallus gallus)

Other forms of this molecule

RAD52 [nucleoplasm]

Inferred From

p-Y104-RAD52 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 104 (in Homo sapiens)

Coordinate

104

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001161231.1, XP_015141265.1, XP_015141256.1

OpenTargets

ENSG00000002016

Ensembl

ENSGALG00010012367, ENSGALT00010029620, ENSGALP00010017234

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