Reactome | BABAM1 [nucleoplasm]

BABAM1

Stable Identifier

R-GGA-5682582-5

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

A0A1D5PX35

Locations in the PathwayBrowser

Expand all

Cell Cycle (Gallus gallus)

- Cell Cycle Checkpoints (Gallus gallus)
  - G2/M Checkpoints (Gallus gallus)
    - G2/M DNA damage checkpoint (Gallus gallus)
      - CHEK2 is recruited to DNA DSBs (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
      - Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)

DNA Repair (Gallus gallus)

- DNA Double-Strand Break Repair (Gallus gallus)
  - DNA Double Strand Break Response (Gallus gallus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Gallus gallus)
      - CHEK2 is recruited to DNA DSBs (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
      - CHEK2 phosphorylates BRCA1 (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
      - Formation of BRCA1-A complex at DNA DSBs (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
      - Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
  - Homology Directed Repair (Gallus gallus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
      - Processing of DNA double-strand break ends (Gallus gallus)
        
        PIAS4 SUMOylates MDC1 (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
  - Nonhomologous End-Joining (NHEJ) (Gallus gallus)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Gallus gallus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Gallus gallus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
      - Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Deubiquitination (Gallus gallus)
    - Metalloprotease DUBs (Gallus gallus)
      - BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)
        
        BRCA1-A Complex:Histone H2A [nucleoplasm] (Gallus gallus)
        
        BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)
        
        BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Gallus gallus)
        
        BRCA1-A Complex [nucleoplasm] (Gallus gallus)
        
        Homologues of BABAM1 [nucleoplasm] (Gallus gallus)
        
        BABAM1 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PX35

Reference Genes

ENSEMBL:ENSGALG00000038189

Other Identifiers

776677

AADN04000367

BABAM1

ENSGALG00000038189

ENSGALP00000057526

ENSGALT00000077981

EntrezGene:776677

GgaAffx.11154.1.S1_at

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0006259

GO:0006950

GO:0008150

GO:0034641

GO:0043226

GO:0043234

GO:0045739

GO:0070531

GO:0070552

IPR026126

UPI00085AD1E9

Participant Of

hasMember

Homologues of BABAM1 [nucleoplasm]

Other forms of this molecule

BABAM1 [cytosol]

Inferred From

BABAM1 [nucleoplasm] (Homo sapiens)