Reactome | TNFRSF10B [plasma membrane]

TNFRSF10B [plasma membrane]

Stable Identifier

R-GGA-5633393

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

TNFRSF10A, A0A3Q3AR39

Locations in the PathwayBrowser

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Programmed Cell Death (Gallus gallus)

- Apoptosis (Gallus gallus)
  - Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
    - Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
      - Dimerization of procaspase-8 (Gallus gallus)
        
        TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - Regulation by c-FLIP (Gallus gallus)
        
        Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
- Regulated Necrosis (Gallus gallus)
  - RIPK1-mediated regulated necrosis (Gallus gallus)
    - Regulation of necroptotic cell death (Gallus gallus)
      - CASP8 activity is inhibited (Gallus gallus)
        
        FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Death Receptor Signalling (Gallus gallus)
  - TRAIL signaling (Gallus gallus)
    - TRAIL binds TRAIL receptors (Gallus gallus)
      - TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
    - TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)
      - TNFRSF10A,B:TNFRSF10D [plasma membrane] (Gallus gallus)
        
        TNFRSF10A:TNFRSF10D [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
    - TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)
      - TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
    - TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)
      - TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
    - TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)
      - TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - TNFSF10:TNFRSF10A,B:FADD:CASP10(1-521) [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
    - Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)
      - TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Gallus gallus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)
      - TNFSF10:TNFRSF10A,B [plasma membrane] (Gallus gallus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Gallus gallus)
        
        Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)
        
        TNFRSF10B [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q3AR39

Gene Names

TNFRSF10B

Reference Genes

BioGPS Gene:373904 TNFRSF10B

ENSEMBL:ENSGALG00000000452

Monarch:373904 TNFRSF10B

NCBI Gene:373904 TNFRSF10B

Reference Transcript

RefSeq:XM_015297294.1 TNFRSF10B

Other Identifiers

373904

GO:0003674

GO:0005515

GO:0005575

GO:0005886

GO:0006915

GO:0007165

GO:0008150

GO:0008219

GO:0009986

GO:0016020

GO:0016021

GO:0036462

GO:0043065

GO:0045569

GO:0110165

GT_A_87_P037581

GT_A_87_P061291

Gga.4589.1.S1_at

Gga.4589.1.S3_at

Participates

as a member of

Homologues of TNFRSF10A [plasma membrane] (Gallus gallus)

Other forms of this molecule

TNFRSF10B [plasma membrane]

Inferred From

TNFRSF10A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_015152780.1

OpenTargets

ENSG00000120889

Ensembl

ENSGALP00000071222, ENSGALT00000095650, ENSGALG00000000452

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