Reactome | MTA3 [nucleoplasm]

MTA3 [nucleoplasm]

Stable Identifier

R-GGA-4657013

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

MTA3, E1C0L3

Locations in the PathwayBrowser

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Chromatin organization (Gallus gallus)

- Chromatin modifying enzymes (Gallus gallus)
  - HDACs deacetylate histones (Gallus gallus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Gallus gallus)
      - HDAC1:2-containing complex [nucleoplasm] (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Gallus gallus)
        
        HDAC1:2-containing complex [nucleoplasm] (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)
    - HDAC1:2-containing complex deacetylate histones (Gallus gallus)
      - HDAC1:2-containing complex [nucleoplasm] (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Gallus gallus)
        
        HDAC1:2-containing complex [nucleoplasm] (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)

Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase I Transcription (Gallus gallus)
  - RNA Polymerase I Promoter Clearance (Gallus gallus)
    - RNA Polymerase I Transcription Initiation (Gallus gallus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - PTEN Regulation (Gallus gallus)
      - Regulation of PTEN gene transcription (Gallus gallus)
        
        SALL4 recruits NuRD to PTEN gene (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Gallus gallus)
        
        SALL4:NuRD [nucleoplasm] (Gallus gallus)
        
        NuRD complex [nucleoplasm] (Gallus gallus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)
        
        MTA3 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1C0L3

Gene Names

MTA3

Reference Genes

BioGPS Gene:421395 MTA3

ENSEMBL:ENSGALG00000009925

ENSEMBL:ENSGALG00010020272.1 MTA3

Monarch:421395 MTA3

NCBI Gene:421395 MTA3

Reference Transcript

RefSeq:XM_015283840.1 MTA3

Other Identifiers

421395

GO:0000122

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0016581

GO:0042826

GO:0043226

GO:0043565

GO:0045893

GO:0046872

GO:0140110

GT_A_87_P011981

GgaAffx.21709.1.S1_s_at

Participates

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Gallus gallus)

Inferred From

MTA3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_015139326.1

OpenTargets

ENSG00000057935

Ensembl

ENSGALT00010048932, ENSGALP00010028919, ENSGALG00010020272