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What is Reactome ?
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phospho-JAK1 [cytosol]
Stable Identifier
R-GGA-451921
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-Y-JAK1, F1NMJ9
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon alpha/beta signaling (Gallus gallus)
Activation of JAK kinases (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Formation of p-STAT1 homodimer (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylation of INFAR1 by TYK2 (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylation of STAT2 (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Recruitment of STAT2 to p-IFNAR1 (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Regulation of IFNA/IFNB signaling (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Release of p-STAT2:p-STAT1 dimer (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interferon gamma signaling (Gallus gallus)
Binding of STAT1 to p-IFNGR1 (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
STAT1 bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNG signaling activates MAPKs (Gallus gallus)
Activated JAK1 binds RAF1 (Gallus gallus)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
JAK1-mediated phosphorylation of RAF1 (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylation of IFNGR1 by JAK kinases (Gallus gallus)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylation of STAT1 at Ser727 (Gallus gallus)
p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylation of STAT1 by JAK kinases (Gallus gallus)
STAT1 bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Release of STAT1 dimer from active receptor unit (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Transphosphorylation of JAK1 (Gallus gallus)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Signaling by CSF3 (G-CSF) (Gallus gallus)
Inactivation of CSF3 (G-CSF) signaling (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Gallus gallus)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Gallus gallus)
CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Gallus gallus)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Gallus gallus)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-10 signaling (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin-15 signaling (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin-21 signaling (Gallus gallus)
IL21 receptor JAK phosphorylation (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL21 receptor STAT binding (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL21 receptor STAT phosphorylation (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
Interleukin-4 and Interleukin-13 signaling (Gallus gallus)
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
JAK1 phosphorylates STAT3,STAT6 (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
STAT3,STAT6 bind p-Y-IL4R (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
phospho-JAK1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NMJ9
Gene Names
JAK1
Reference Genes
BioGPS Gene:395681 JAK1
ENSEMBL:ENSGALG00000011031
Monarch:395681 JAK1
NCBI Gene:395681 JAK1
UCSC:F1NMJ9 JAK1
Reference Transcript
RefSeq:XM_015290965.1 JAK1
Other Identifiers
395681
GO:0003824
GO:0004713
GO:0004715
GO:0005131
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0007259
GO:0009898
GO:0016020
GO:0016740
GO:0019221
GO:0019903
GO:0030154
GO:0031234
GO:0031625
GO:0034112
GO:0035556
GO:0035723
GO:0035771
GO:0038110
GO:0038113
GO:0038154
GO:0043226
GO:0046677
GO:0060333
GO:0060337
GO:0060397
GO:0070102
GO:0140096
GO:0140105
GO:0150105
GO:1900182
GO:1903672
GT_A_87_P079701
GT_A_87_P079706
GT_A_87_P079711
Gga.2435.1.S1_at
Gga.2435.1.S2_at
GgaAffx.11846.1.S1_s_at
Participates
as a component of
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Gallus gallus)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Gallus gallus)
p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Gallus gallus)
p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL21R:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Gallus gallus)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Gallus gallus)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
p-IFNGR1:p-JAK1 [plasma membrane] (Gallus gallus)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-JAK1 [cytosol]
phospho-JAK1 [cytosol]
phospho-JAK1 [cytosol]
JAK1 [cytosol]
Inferred From
p-Y-JAK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_015146451.1
ENSEMBL
ENSGALT00010059742
,
ENSGALP00010036502
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