Reactome | IL2RA [plasma membrane]

IL2RA [plasma membrane]

Stable Identifier

R-GGA-450046

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

Q90WJ4

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-2 family signaling (Gallus gallus)
      - Interleukin receptor SHC signaling (Gallus gallus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
      - Interleukin receptor SHC signaling (Gallus gallus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Gallus gallus)
        
        IL2RA [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q90WJ4

Reference Genes

BioGPS Gene:395294

ENSEMBL:ENSGALG00000042471

KEGG Gene (Gallus gallus):395294

Monarch:395294

NCBI Gene:395294

Reference Transcript

RefSeq:NM_204596.1

Participates

as a component of

Inferred From

IL2RA [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_989927.1

Cite Us!