Reactome | GPR65 [plasma membrane]

GPR65 [plasma membrane]

Stable Identifier

R-GGA-444624

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

GPR65, F1NJ83

Locations in the PathwayBrowser

Expand all

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors:H+ [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors:H+ [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors:H+ [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors:H+ [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
      - The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
        
        GPCRs that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors:H+ [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)
        
        pH sensing receptors:H+ [plasma membrane] (Gallus gallus)
        
        pH sensing receptors [plasma membrane] (Gallus gallus)
        
        GPR65 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NJ83

Gene Names

GPR65

Reference Genes

BioGPS Gene:423395 GPR65

ENSEMBL:ENSGALG00000010595

ENSEMBL:ENSGALG00010017858.1 GPR65

KEGG Gene (Gallus gallus):423395 GPR65

Monarch:423395 GPR65

NCBI Gene:423395 GPR65

Reference Transcript

Other Identifiers

423395

GO:0004930

GO:0005886

GO:0007010

GO:0007165

GO:0007186

GO:0007189

GO:0007200

GO:0010447

GO:0016020

GO:0023052

GO:0035025

GO:0051496

GO:0060089

Gga.10465.1.S1_s_at

GgaAffx.23262.1.S1_at

Participates

as a member of

pH sensing receptors [plasma membrane] (Gallus gallus)

Inferred From

GPR65 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_004941908.1, XP_015143215.1, XP_015143214.1, XP_015143213.1, XP_421305.1, XP_015143212.1

OpenTargets

ENSG00000140030

Ensembl

ENSGALT00010043163, ENSGALT00010043168, ENSGALP00010025639, ENSGALP00010025636, ENSGALG00010017858