Cis-heterodimerization of NgCAM and Axonin-1

Stable Identifier
R-GGA-443769
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cis-heterodimerization of NgCAM and Axonin-1
By analogy to the well-studied chicken system, L1 can be coexpressed with axonin-1 (TAG-1/Contactin-2) on same growth cone membrane and the two proteins form a cis-heterodimer required for neurite growth.
Literature References
PubMed ID Title Journal Year
9837910 Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion

Karagogeos, D, Malhotra, JD, Tsiotra, P, Hortsch, M

J Biol Chem 1998
8978825 Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion

Ziegler, U, Sonderegger, P, Rader, C, Berger, P, Kunz, S, Buchstaller, A, Kunz, B

J Cell Biol 1996
12139915 Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members

Karagogeos, D, Pavlou, O, Kutsche, M, Faivre-Sarrailh, C, Falk, J, Theodorakis, K, Schachner, M

Mol Cell Neurosci 2002
Participants
Input
Output
Orthologous Events
Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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