Reactome | Association of LBP with bacterial LPS

Association of LBP with bacterial LPS

Stable Identifier

R-GGA-433940

Type

Reaction [binding]

Species

Gallus gallus

Compartment

extracellular region

ReviewStatus

5/5

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The role of chicken lipopolysaccharide-binding protein (LBP) remains unclear. Inspection of the chicken genome showed no ortholog of human LBP (Keestra et al 2008), and LPS induced the functional activation of heterophils without the presence of LBP. Nevertheless, in the reaction shown here we annotated hypothetical chicken LPB using the data and suggestions reported by Kogut et al. (2005), that LBP and CD14/TLR4 induction is directly involved in LPS-mediated functional activation of chicken heterophils.

Literature References

PubMed ID	Title	Journal	Year
2477488	Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles Ramos, RA, Ulevitch, RJ, Wright, SD, Tobias, PS	J Exp Med	1989
16335810	Lipopolysaccharide binding protein/CD14/ TLR4-dependent recognition of salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells Kogut, MH, Kaiser, P, He, H	Anim Biotechnol	2005

Participants

Input

Output

LBP : LPS complex [extracellular region] (Gallus gallus)

Participates

as an event of

TLR4 cascade (Gallus gallus)

Authored

Shamovsky, V (2010-05-18)

Reviewed

D'Eustachio, P (2010-10-16)

Created

Shamovsky, V (2009-08-27)

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