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Association of LBP with bacterial LPS
Stable Identifier
R-GGA-433940
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR4 cascade (Gallus gallus)
Association of LBP with bacterial LPS (Gallus gallus)
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The role of chicken lipopolysaccharide-binding protein (LBP) remains unclear. Inspection of the chicken genome showed no ortholog of human LBP (Keestra et al 2008), and LPS induced the functional activation of heterophils without the presence of LBP. Nevertheless, in the reaction shown here we annotated hypothetical chicken LPB using the data and suggestions reported by Kogut et al. (2005), that LBP and CD14/TLR4 induction is directly involved in LPS-mediated functional activation of chicken heterophils.
Literature References
PubMed ID
Title
Journal
Year
2477488
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles
Ramos, RA
,
Ulevitch, RJ
,
Wright, SD
,
Tobias, PS
J Exp Med
1989
16335810
Lipopolysaccharide binding protein/CD14/ TLR4-dependent recognition of salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells
Kogut, MH
,
Kaiser, P
,
He, H
Anim Biotechnol
2005
Participants
Input
Lipopolysaccharide binding protein [extracellular region]
(Gallus gallus)
LPS [extracellular region]
Output
LBP : LPS complex [extracellular region]
(Gallus gallus)
Participates
as an event of
TLR4 cascade (Gallus gallus)
Authored
Shamovsky, V (2010-05-18)
Reviewed
D'Eustachio, P (2010-10-16)
Created
Shamovsky, V (2009-08-27)
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