viral dsRNA : TRL3 recruits TICAM1

Stable Identifier
R-GGA-433815
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
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Chicken TICAM1 encodes a 735 amino-acid protein that shares 31% sequence identity with its human and mouse orthologs.

TICAM1 (or TRIF) is known to be an essential and exclusive adaptor used by TLR3 ; all the poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF–/– mice (Yamamoto et al. 2003).

Human TICAM1 consists of an N-terminal region (1–234), a TIR domain (235–500), and a C-terminal region (501–680).

The N-terminal region of TICAM1 harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases.

The C-terminal region of TICAM1 can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex .

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H

Science 2003
17676477 Molecular cloning and expression analysis of chicken MyD88 and TRIF genes

Brisbin, JT, Lambourne, MD, Sharif, S, Mayameei, A, Sarson, AJ, Wheaton, S

DNA Seq 2007
12539043 TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Matsumoto, M, Oshiumi, H, Funami, K, Akazawa, T, Seya, T

Nat Immunol 2003
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