Human TICAM1 consists of an N-terminal region (1–234), a TIR domain (235–500), and a C-terminal region (501–680).
The N-terminal region of TICAM1 harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases.
The C-terminal region of TICAM1 can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex .
Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H
Brisbin, JT, Lambourne, MD, Sharif, S, Mayameei, A, Sarson, AJ, Wheaton, S
Matsumoto, M, Oshiumi, H, Funami, K, Akazawa, T, Seya, T
© 2024 Reactome
