viral dsRNA: TLR3: TICAM1 recruits TRAF6

Stable Identifier
R-GGA-433808
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
viral dsRNA: TLR3: TICAM1 recruits TRAF6
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TRAF6 is recruited to the N-terminal domain of TICAM1 and this event is followed by auto polyubiquitination and oligomerization of TRAF6. Chicken TRAF6 protein, confirmed by transcript evidence, shows 76% amino acid sequence identity with human TRAF6.
Literature References
PubMed ID Title Journal Year
16306937 Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Hsu, LC, Raz, E, Häcker, G, Karin, M, Kamps, MP, Mann, M, Kratchmarova, I, Redecke, V, Blagoev, B, Häcker, H, Wagner, H, Wang, GG

Nature 2006
Participants
Input
Output
Participates
as an event of
Inferred From
Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)
Authored
Shamovsky, V  (2009-08-27)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-08-27)
Cite Us!