Reactome | NEFL [cytosol]

NEFL [cytosol]

Stable Identifier

R-GGA-432284

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

A0A1L1RUS3

Locations in the PathwayBrowser

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Neuronal System (Gallus gallus)

- Transmission across Chemical Synapses (Gallus gallus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
    - Activation of NMDA receptors and postsynaptic events (Gallus gallus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)
        
        Ca2+ influx into the post-synaptic cell (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        NEFL [cytosol] (Gallus gallus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        NEFL [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        NEFL [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1L1RUS3

Reference Genes

ENSEMBL:ENSGALG00000000314

Other Identifiers

GO:0000226

GO:0000902

GO:0003674

GO:0005198

GO:0005200

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005882

GO:0005883

GO:0006810

GO:0006950

GO:0007010

GO:0008022

GO:0008089

GO:0008090

GO:0008150

GO:0008219

GO:0014012

GO:0019896

GO:0022607

GO:0030154

GO:0030424

GO:0030674

GO:0030705

GO:0031133

GO:0031594

GO:0033693

GO:0034330

GO:0040011

GO:0042802

GO:0043005

GO:0043226

GO:0043524

GO:0045109

GO:0045110

GO:0048812

GO:0048856

GO:0050772

GO:0050877

GO:0050885

GO:0060052

GO:0061564

GO:0098685

GO:0099182

GO:0099184

GO:0099185

GO:1904115

GT_A_87_P140893

GT_A_87_P223328

Participant Of

hasComponent

Inferred From

NEFL [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSGALG00000000314, ENSGALP00000062579, ENSGALT00000087263

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