Reactome | 4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3

4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3

Stable Identifier

R-GGA-421439

Type

Reaction [transition]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

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4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3

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Cytosolic HMBS (hydroxymethylbilane synthase) catalyzes the reaction of four molecules of porphobilinogen and one of H2O to form hydroxymethylbilane and four molecules of NH3. Chicken HMBS is known only as the inferred product of a gene discovered by analysis of the chicken genomic DNA sequence. Its requirement for dipyrromethane as a cofactor and its catalytic activity are inferred from the properties of its better-studied human counterpart.

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