4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3

Stable Identifier
R-GGA-421439
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Cytosolic HMBS (hydroxymethylbilane synthase) catalyzes the reaction of four molecules of porphobilinogen and one of H2O to form hydroxymethylbilane and four molecules of NH3. Chicken HMBS is known only as the inferred product of a gene discovered by analysis of the chicken genomic DNA sequence. Its requirement for dipyrromethane as a cofactor and its catalytic activity are inferred from the properties of its better-studied human counterpart.

Participants
Participates
Catalyst Activity

hydroxymethylbilane synthase activity of HMBS holoenzyme [cytosol]

Inferred From
Authored
Created
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