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4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3
Stable Identifier
R-GGA-421439
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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Metabolism (Gallus gallus)
Heme synthesis (Gallus gallus)
4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic HMBS (hydroxymethylbilane synthase) catalyzes the reaction of four molecules of porphobilinogen and one of H2O to form hydroxymethylbilane and four molecules of NH3. Chicken HMBS is known only as the inferred product of a gene discovered by analysis of the chicken genomic DNA sequence. Its requirement for dipyrromethane as a cofactor and its catalytic activity are inferred from the properties of its better-studied human counterpart.
Participants
Input
H2O [cytosol]
x 4
PBG [cytosol]
Output
HMBL [cytosol]
x 4
NH3 [cytosol]
Participates
as an event of
Heme synthesis (Gallus gallus)
Catalyst Activity
hydroxymethylbilane synthase activity of HMBS holoenzyme [cytosol]
Physical Entity
HMBS holoenzyme [cytosol]
(Gallus gallus)
Activity
hydroxymethylbilane synthase activity (GO:0004418)
Inferred From
4 PBGs bind to form HMB (Homo sapiens)
Authored
D'Eustachio, P (2009-05-19)
Created
D'Eustachio, P (2009-05-19)
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