hypoxanthine + H2O + NAD+ => xanthine + NADH + H+

Stable Identifier
R-GGA-421161
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
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hypoxanthine + H2O + NAD+ => xanthine + NADH + H+
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Cytosolic xanthine dehydrogenase (XDH) catalyzes the reaction of hypoxanthine, H2O, and NAD+ to form xanthine and NADH + H+. Studies of partially purified enzyme from chicken liver established its dehydrogenase activity (and lack of oxidase activity, in contrast to homologous mammalian enzymes such as the one from bovine milk) (Richert and Westerfeld 1951; Morell 1955; Remy et al. 1955). While the gene encoding chicken XDH has been cloned and shown to encode active enzyme (Sato et al. 1995), the pure enzyme has not been extensively characterized and is therefore annotated here simply as a monomer with no cofactors.

Literature References
PubMed ID Title Journal Year
7852355 The structure of chicken liver xanthine dehydrogenase. cDNA cloning and the domain structure

Amaya, Y, Nishino, T, Sato, A, Nishino, T, Noda, K

J Biol Chem 1995
13271394 Purification and characterization of chicken liver xanthine dehydrogenase

Remy, CN, Richert, DA, Doisy, RJ, Westerfeld, WW, Wells, IC

J Biol Chem 1955
14827888 Xanthine oxidase in different species

Richert, DA, Westerfeld, WW

Proc Soc Exp Biol Med 1951
14363260 The oxidation of reduced xanthine dehydrogenase in chicken liver

Morell, DB

Biochim Biophys Acta 1955
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Catalyst Activity

hypoxanthine dehydrogenase activity of XDH [cytosol]

Physical Entity
XDH [cytosol] (Gallus gallus)
Activity
hypoxanthine dehydrogenase activity (GO:0070674)
Authored
D'Eustachio, P  (2009-05-15)
Created
D'Eustachio, P  (2009-05-15)
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