Reactome | GRIN1 [plasma membrane]

GRIN1 [plasma membrane]

Stable Identifier

R-GGA-419564

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

GRIN1, Q6R6I2

Locations in the PathwayBrowser

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Developmental Biology (Gallus gallus)

- Nervous system development (Gallus gallus)
  - Axon guidance (Gallus gallus)
    - EPH-Ephrin signaling (Gallus gallus)
      - EPHB-mediated forward signaling (Gallus gallus)
        
        EPHB phosphorylates TIAM1 (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        EPHB:NMDAR binds TIAM1 (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)

Neuronal System (Gallus gallus)

- Protein-protein interactions at synapses (Gallus gallus)
  - Synaptic adhesion-like molecules (Gallus gallus)
    - SALM2 associate with AMPA and NMDA receptors (Gallus gallus)
      - AMPA, NMDA receptors [plasma membrane] (Gallus gallus)
        
        NMDA receptor complex [plasma membrane] (Gallus gallus)
        
        NMDA receptor [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Gallus gallus)
        
        AMPA, NMDA receptors [plasma membrane] (Gallus gallus)
        
        NMDA receptor complex [plasma membrane] (Gallus gallus)
        
        NMDA receptor [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
- Transmission across Chemical Synapses (Gallus gallus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
    - Activation of NMDA receptors and postsynaptic events (Gallus gallus)
      - Assembly and cell surface presentation of NMDA receptors (Gallus gallus)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Gallus gallus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2C di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)
        
        Ca2+ influx into the post-synaptic cell (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2C di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN1 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q6R6I2

Gene Names

GRIN1

Reference Genes

BioGPS Gene:404296 GRIN1

ENSEMBL:ENSGALG00000008898

KEGG:gga:404296 GRIN1

Monarch:404296 GRIN1

NCBI Gene:404296 GRIN1

UCSC:Q6R6I2 GRIN1

Reference Transcript

RefSeq:NM_206979.1 GRIN1

Other Identifiers

404296

GO:0004972

GO:0005215

GO:0005262

GO:0005886

GO:0006811

GO:0006812

GO:0007215

GO:0007268

GO:0015276

GO:0015280

GO:0016020

GO:0016594

GO:0016595

GO:0017146

GO:0022824

GO:0022849

GO:0023052

GO:0030425

GO:0034220

GO:0035235

GO:0035725

GO:0038023

GO:0042391

GO:0043005

GO:0045202

GO:0045211

GO:0045471

GO:0055085

GO:0060089

GO:0070588

GO:0097553

GO:1905429

GT_A_87_P035151

GT_A_87_P068076

GT_A_87_P141328

GT_Xhyb_Chicken_CO759421_3893

Gga.12184.1.S1_at

Participates

as a component of

Other forms of this molecule

GRIN1 [endoplasmic reticulum membrane]

Inferred From

GRIN1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_996862.1

ENSEMBL

ENSGALT00010069091, ENSGALP00010042533

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