5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O

Stable Identifier
R-GGA-419253
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

The IMP cyclohydrolase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) to form inosine 5'-monophosphate and water. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
IMP cyclohydrolase activity of ATIC dimer [cytosol]
Physical Entity
Activity
Authored