5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O

Stable Identifier
R-GGA-419253
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
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5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
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The IMP cyclohydrolase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) to form inosine 5'-monophosphate and water. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).

Literature References
PubMed ID Title Journal Year
7470484 On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

Mueller, WT, Benkovic, SJ

Biochemistry 1981
11323713 Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Beardsley, GP, Greasley, SE, Benkovic, SJ, Ramcharan, J, Horton, P, Wilson, IA

Nat Struct Biol 2001
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Catalyst Activity

IMP cyclohydrolase activity of ATIC dimer [cytosol]

Physical Entity
ATIC dimer [cytosol] (Gallus gallus)
Activity
IMP cyclohydrolase activity (GO:0003937)
Authored
D'Eustachio, P  (2009-04-29)
Created
D'Eustachio, P  (2009-04-29)
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