The IMP cyclohydrolase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) to form inosine 5'-monophosphate and water. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).
Mueller, WT, Benkovic, SJ
Beardsley, GP, Greasley, SE, Benkovic, SJ, Ramcharan, J, Horton, P, Wilson, IA
IMP cyclohydrolase activity of ATIC dimer [cytosol]
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