5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O

Stable Identifier
R-GGA-419253
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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The IMP cyclohydrolase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) to form inosine 5'-monophosphate and water. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).

Literature References
PubMed ID Title Journal Year
7470484 On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

Mueller, WT, Benkovic, SJ

Biochemistry 1981
11323713 Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Beardsley, GP, Greasley, SE, Benkovic, SJ, Ramcharan, J, Horton, P, Wilson, IA

Nat Struct Biol 2001
Participants
Participates
Catalyst Activity

IMP cyclohydrolase activity of ATIC dimer [cytosol]

Authored
Created
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