5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O

Stable Identifier
R-GGA-419253
Type
Reaction
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
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Summation

The IMP cyclohydrolase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) to form inosine 5'-monophosphate and water. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).

Literature References
PubMed ID Title Journal Year
11323713 Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Greasley, SE, Horton, P, Ramcharan, J, Beardsley, GP, Benkovic, SJ, Wilson, IA

Nat Struct Biol 2001
7470484 On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

Mueller, WT, Benkovic, SJ

Biochemistry 1981
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
IMP cyclohydrolase activity of ATIC dimer [cytosol]
Physical Entity
ATIC dimer [cytosol]
Activity
IMP cyclohydrolase activity (0003937)
Authored
D'Eustachio, P  (2009-04-30)