5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate

Stable Identifier
R-GGA-419145
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

The phosphoribosylglycinamide formyltransferase activity of cytosolic GART trifunctional enzyme (trifunctional purine biosynthetic protein adenosine-3) catalyzes the reaction of 5-phosphoribosylglycinamide (GAR) and 10-formyl-tetrahydrofolate to form 5'-phosphoribosylformylglycinamide (FGAR) and tetrahydrofolate. GART trifunctional protein has been purified from chicken liver (Daubner et al. 1985), and a cDNA encoding the chicken enzyme has been identified based on sequence similarities and its ability to complement E. coli cells whose homologous purine biosynthesis genes were mutated (Aimi et al. 1990). The subcellular location of the chicken enzyme is inferred from that of its better-characterized mammalian counterparts.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoribosylglycinamide formyltransferase activity of GART [cytosol]
Physical Entity
Activity
Authored