The human shelterin complex (Liu et al. 2004; Palm and de Lange 2008) contains six proteins, TRF1, TRF2, POT1, RAP1 (TERF2IP, TRF2IP), TPP1 (ACD), and TIN2 (TINF2). Chicken proteins homologous to the first four of these have been identified: TRF1 (Okamoto et al. 2008), TRF2 (Konrad et al. 1999), POT1 (Wei and Price 2004; Churikov et al. 2006), and TRF2IP (Tan et al. 2003). A possible chicken ortholog of TPP1 has been identified, but to date no chicken counterpart of human TIN2 has been found.
de Lange, T, Palm, W
Okamoto, K, Shinkai, Y, Tachibana, M, Iwano, T
Wei, C, Price, CM, Tan, M
Nikitina, T, Woodcock, CL
Easty, DJ, Farr, CJ, Konrad, JP, Mills, W
Wei, C, Price, CM
Churikov, D, Wei, C, Price, CM
O'Connor, MS, Songyang, Z, Qin, J, Liu, D
Moss, H, Bianchi, A, de Lange, T, Stansel, RM, Rosenfield, S, Comeau, L, Griffith, JD
© 2024 Reactome