Reactome | SPTAN1 [cytosol]

SPTAN1 [cytosol]

Stable Identifier

R-GGA-391563

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

SPTA1, A0A8V1AH25

Locations in the PathwayBrowser

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Developmental Biology (Gallus gallus)

- Nervous system development (Gallus gallus)
  - Axon guidance (Gallus gallus)
    - NCAM signaling for neurite out-growth (Gallus gallus)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Gallus gallus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Asparagine N-linked glycosylation (Gallus gallus)
    - Transport to the Golgi and subsequent modification (Gallus gallus)
      - ER to Golgi Anterograde Transport (Gallus gallus)
        
        COPI-mediated anterograde transport (Gallus gallus)
        
        ARFGAPs stimulate ARF GTPase activity (Gallus gallus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Gallus gallus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - ER to Golgi Anterograde Transport (Gallus gallus)
    - COPI-mediated anterograde transport (Gallus gallus)
      - ARFGAPs stimulate ARF GTPase activity (Gallus gallus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Gallus gallus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Gallus gallus)
        
        Spectrin tetramer [cytosol] (Gallus gallus)
        
        SPTA:SPTB [cytosol] (Gallus gallus)
        
        SPTAN1 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1AH25

Gene Names

SPTAN1

Reference Genes

ENSEMBL:ENSGALG00010028556.1

UCSC:A0A8V1AH25 SPTAN1

Reference Transcript

RefSeq:XM_015279290.1 SPTAN1

Other Identifiers

374234

GO:0003779

GO:0005509

GO:0005515

GO:0005516

GO:0005737

GO:0005856

GO:0005938

GO:0008092

GO:0015630

GO:0046872

GO:0051693

GT_A_87_P037669

GT_A_87_P058971

GT_A_87_P068331

GT_A_87_P121123

GT_A_87_P126178

GT_A_87_P127653

GT_A_87_P193673

GT_A_87_P264038

GT_A_87_P278903

GT_Xhyb_Chicken_CN225656_3275

Gga.11413.1.S1_s_at

Gga.4441.1.S1_at

GgaAffx.21304.1.S1_s_at

Participates

as a component of

SPTA:SPTB [cytosol] (Gallus gallus)

Other forms of this molecule

SPTAN1 [specific granule lumen]

SPTAN1 [extracellular region]

SPTAN1 [tertiary granule lumen]

SPTAN1 [cytosol]

Inferred From

Spectrin alpha chain [cytosol] (Homo sapiens)

SPTA1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015134776.1

ENSEMBL

ENSGALP00010042615, ENSGALT00010069173, ENSGALG00010028556

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