Reactome | BMI1 [nucleoplasm]

BMI1 [nucleoplasm]

Stable Identifier

R-GGA-389121

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

BMI1, Q5SDR3

Locations in the PathwayBrowser

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Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional Regulation by E2F6 (Gallus gallus)
      - E2F6 binds the PRC1 complex (Gallus gallus)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Gallus gallus)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Gallus gallus)
        
        BMI1,PCGF2 [nucleoplasm] (Gallus gallus)
        
        BMI1 [nucleoplasm] (Gallus gallus)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Gallus gallus)
        
        BMI1,PCGF2 [nucleoplasm] (Gallus gallus)
        
        BMI1 [nucleoplasm] (Gallus gallus)
    - Transcriptional regulation by RUNX1 (Gallus gallus)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Gallus gallus)
        
        RUNX1 binds PRC1 complexes (Gallus gallus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        BMI1 [nucleoplasm] (Gallus gallus)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Gallus gallus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        BMI1 [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - PTEN Regulation (Gallus gallus)
      - Regulation of PTEN gene transcription (Gallus gallus)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Gallus gallus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Gallus gallus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        BMI1 [nucleoplasm] (Gallus gallus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        BMI1 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5SDR3

Gene Names

BMI1

Reference Genes

BioGPS Gene:493647 BMI1

ENSEMBL:ENSGALG00000041267

KEGG:gga:493647 BMI1

Monarch:493647 BMI1

NCBI Gene:493647 BMI1

UCSC:Q5SDR3 BMI1

Reference Transcript

RefSeq:NM_001007988.1 BMI1

Other Identifiers

493647

GO:0000122

GO:0000151

GO:0000792

GO:0000978

GO:0001501

GO:0001701

GO:0002376

GO:0003677

GO:0003682

GO:0005634

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006346

GO:0006355

GO:0006959

GO:0007420

GO:0008270

GO:0010468

GO:0016604

GO:0021903

GO:0030097

GO:0030890

GO:0031519

GO:0033092

GO:0035102

GO:0043226

GO:0043565

GO:0045814

GO:0046872

GO:0048103

GO:0048146

GO:0048704

GO:0048706

GO:0048856

GO:0051443

GO:0071535

GO:0097027

GO:0097190

GO:0098772

GO:1990841

GO:2000011

GO:2001234

GT_A_87_P013245

GT_A_87_P054806

GT_Xhyb_Chicken_CN223985_2825

Gga.6243.1.S1_at

Gga.6376.1.S1_at

Participates

as a component of

as a member of

BMI1,PCGF2 [nucleoplasm] (Gallus gallus)

Other forms of this molecule

BMI1 [nucleoplasm]

phospho-BMI1 [nucleoplasm]

Inferred From

BMI1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001007989.1

ENSEMBL

ENSGALP00010005716, ENSGALT00010009779, ENSGALG00010004188

PRO

Q5SDR3

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