malate <=> fumarate + H2O

Stable Identifier
R-GGA-373141
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Mitochondrial FH (fumarate hydratase) catalyzes the reversible reaction of malate to form fumarate and H2O. No chicken enzyme capable of catalyzing this reaction has been identified, although an open reading frame capable of encoding a protein closely similar to authentic human mitochondrial FH has been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart (Sudarshan et al.2007, Tomnlinson et al. 2002).

Literature References
PubMed ID Title Journal Year
17211469 HIF and fumarate hydratase in renal cancer

Sudarshan, S, Neckers, L, Linehan, WM

Br. J. Cancer 2007
11865300 Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Eklund, C, Barclay, E, Rowan, AJ, Tomlinson, IP, Sistonen, P, Karhu, A, Bevan, S, Jaeger, EE, Gorman, P, Hearle, N, Houlston, RS, Olpin, S, Aaltonen, LA, Vilkki, S, Rahman, S, Alam, NA, Barker, K, Hietala, M, Paetau, A, Launonen, V, Lehtonen, R, Lamlum, H, Laiho, P, Salovaara, R, Leigh, I, Aittomäki, K, Kelsell, D, Herva, R, Vierimaa, O, Kiuru, M, Roylance, RR

Nat. Genet. 2002
Participants
Participates
Event Information
Catalyst Activity

fumarate hydratase activity of FH [mitochondrial matrix]

Created
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