MDH2 (mitochondrial malate dehydrogenase) catalyzes the reversible reaction of malate and NAD+ to form oxaloacetate and NADH + H+. No chicken enzyme capable of catalyzing this reaction has been identified, although an open reading frame capable of encoding a protein closely similar to authentic human mitochondrial malate dehydrogenase (MDH2) has been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart.
L-malate dehydrogenase activity of MDH2 [mitochondrial matrix]
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