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XP-C binds to RAD23B forming a heterodimer
Stable Identifier
R-GGA-353524
Type
Reaction [binding]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA replication and repair (Gallus gallus)
DNA repair (Gallus gallus)
Nucleotide Excision Repair (Gallus gallus)
DNA damage recognition in global genomic repair (Gallus gallus)
XP-C binds to RAD23B forming a heterodimer (Gallus gallus)
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The evidence for chicken genes, XP-C (Xeroderma pigmentosum group C-complementing protein) and RAD23B (UV excision repair protein RAD23 homolog B) is only at the transcriptional level. The predicted proteins share 50% homology with corresponding human proteins. The association of XP-C, RAD23B and the subsequent binding of the complex to damaged DNA sites where inferred from corresponding human reaction. However, evidence from studies using chicken cells suggest subsequent recruitments of repair proteins at the damaged DNA sites indicating an existence of Global Genomic Nucleotide Excision Repair in place.
Participants
Input
RAD23B [nucleoplasm]
(Gallus gallus)
XPC [nucleoplasm]
(Gallus gallus)
Output
XP-C-RAD23B heterodimer [nucleoplasm]
(Gallus gallus)
Participates
as an event of
DNA damage recognition in global genomic repair (Gallus gallus)
Inferred From
XPC binds RAD23 and CETN2 (Homo sapiens)
Authored
Saxena, A (2008-07-07)
Reviewed
Borowiec, JA (2009-04-24)
Created
Saxena, A (2008-06-12)
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