Translesion synthesis by Pol kappa

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R-GGA-353503
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Gallus gallus
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Vertebrate Pol kappa belongs to the DNA polymerase Y family, as do most translesion synthesis (TLS) polymerases. Chicken Pol kappa is involved in TLS across from UV photoproducts. DT40 chicken cells defective in both Pol kappa and Rad18 (a regulator of Pol kappa, which regulates TLS in yeast) showed an additive effect on UV sensitivity. Interestingly, the level of sister chromatid exchange, which reflects HR mediated repair, was elevated in normally cycling pol kappa cells. This implies functional redundancy between HR and Pol kappa in maintaining chromosomal DNA. Thus, vertebrate Pol kappa is involved in Rad18 independent TLS of UV damage and plays a role in maintaining genomic stability (Okada et al. 2002; Takenaka et al. 2006).

Literature References
PubMed ID Title Journal Year
16308320 Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage

Takenaka, K, Ogi, T, Okada, T, Sonoda, E, Guo, C, Friedberg, EC, Takeda, S

J Biol Chem 2006
12356753 Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage

Okada, T, Sonoda, E, Yamashita, YM, Koyoshi, S, Tateishi, S, Yamaizumi, M, Takata, M, Ogawa, O, Takeda, S

J Biol Chem 2002
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