Recruitment of repair factors to form the preincision complex

Stable Identifier
R-GGA-353476
Type
Reaction [binding]
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of XP-C:RAD23B complex to the damaged site on the DNA substrate is followed by recruitment of XP-A and the RPA heterotrimer, initiating formation of the incision complex. This includes a serial assembly of the remainder of the NER (nucleotide excision repair) machinery consisting of TFIIH, XPG, SNM1 family proteins etc. The action of DNA helicases in the TFIIH complex partially denatures the DNA template generating a bubble structure and exposing a fragment of ssDNA containing the lesion for endonuclease activity. The subsequent events involving, formation of an active incision complex around the bubble structure by specific NER endonucleases and leading to the excision of ~27 30 bp of damaged ssDNA are not well characterized in chicken.

Literature References
PubMed ID Title Journal Year
1764072 Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster

Shimamoto, T, Kohno, K, Tanaka, K, Okada, Y

Biochem Biophys Res Commun 1991
15572677 DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation

Ishiai, M, Kimura, M, Namikoshi, K, Yamazoe, M, Yamamoto, K, Arakawa, H, Agematsu, K, Matsushita, N, Takeda, S, Buerstedde, JM, Takata, M

Mol Cell Biol 2004
12773817 cDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein

Fu, D, Wakasugi, M, Ishigaki, Y, Nikaido, O, Matsunaga, T

Genes Genet Syst 2003
15642098 Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis

Caldwell, RB, Kierzek, AM, Arakawa, H, Bezzubov, Y, Zaim, J, Fiedler, P, Kutter, S, Blagodatski, A, Kostovska, D, Koter, M, Plachy, J, Carninci, P, Hayashizaki, Y, Buerstedde, JM

Genome Biol 2005
Participants
Participant Of
Authored
Reviewed
Created