Translesion synthesis by Pol zeta

Stable Identifier
R-GGA-353473
Type
Pathway
Species
Gallus gallus
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Pol zeta is a heterodimer of REV3L and MAD2L2 (REV7) proteins. Its polymerase activity can bypass pyrimidine dimers and other adducts in DNA (Diaz et al. 2001; Nojima et al. 2005; Okada et al. 2005).

Literature References
PubMed ID Title Journal Year
16357182 Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells

Nojima, K, Hochegger, H, Saberi, A, Fukushima, T, Kikuchi, K, Yoshimura, M, Orelli, BJ, Bishop, DK, Hirano, S, Ohzeki, M, Ishiai, M, Yamamoto, K, Takata, M, Arakawa, H, Buerstedde, JM, Yamazoe, M, Kawamoto, T, Araki, K, Takahashi, JA, Hashimoto, N, Takeda, S, Sonoda, E

Cancer Res 2005
15988022 Multiple roles of vertebrate REV genes in DNA repair and recombination

Okada, T, Sonoda, E, Yoshimura, M, Kawano, Y, Saya, H, Kohzaki, M, Takeda, S

Mol Cell Biol 2005
11205333 Evolution and the molecular basis of somatic hypermutation of antigen receptor genes

Diaz, M, Flajnik, MF, Klinman, N

Philos Trans R Soc Lond B Biol Sci 2001
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