Nucleotide Excision Repair

Stable Identifier
R-GGA-353303
Type
Pathway
Species
Gallus gallus
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In nucleotide excision repair (NER) endonucleases incise the affected DNA strand on both the sides of the base damage, allowing removal of an oligonucleotide containing the damage and subsequent replacement of the missing DNA piece by DNA synthesis and ligation. In humans, NER is well characterized as two related pathways called global genomic repair (GG-NER, transcription-independent) and transcription-coupled NER (TC-NER). Except for the initial recognition of DNA damage, these pathways are very similar and utilize the same molecular machinery to repair the damage. In chicken, however, these pathways are not characterized in detail.

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