Elongation by Pol zeta complex

Stable Identifier
Reaction [transition]
Gallus gallus
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Polymerase activity of Pol zeta is attributed to its REV3L subunit. REV7 is also a part of Pol zeta complex although its function is not yet identified. Pol zeta bypasses the lesion and restores DNA replication. The reaction takes place in the nucleus ((Diaz et al. 2001; Nojima et al. 2005; Okada et al. 2005).

Literature References
PubMed ID Title Journal Year
16357182 Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells

Nojima, K, Hochegger, H, Saberi, A, Fukushima, T, Kikuchi, K, Yoshimura, M, Orelli, BJ, Bishop, DK, Hirano, S, Ohzeki, M, Ishiai, M, Yamamoto, K, Takata, M, Arakawa, H, Buerstedde, JM, Yamazoe, M, Kawamoto, T, Araki, K, Takahashi, JA, Hashimoto, N, Takeda, S, Sonoda, E

Cancer Res 2005
15988022 Multiple roles of vertebrate REV genes in DNA repair and recombination

Okada, T, Sonoda, E, Yoshimura, M, Kawano, Y, Saya, H, Kohzaki, M, Takeda, S

Mol Cell Biol 2005
11205333 Evolution and the molecular basis of somatic hypermutation of antigen receptor genes

Diaz, M, Flajnik, MF, Klinman, N

Philos Trans R Soc Lond B Biol Sci 2001
Participant Of
Catalyst Activity
Catalyst Activity
DNA polymerase activity of Pol zeta complex [nucleoplasm]
Physical Entity