Base Excision Repair, AP site formation by depyrimidination

Stable Identifier
R-GGA-353234
Type
Pathway
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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Base excision repair is initiated by DNA glycosylases that hydrolytically cleave the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base. Depyrimidination of a damaged nucleotide is mediated by a pyrimidine specific DNA glycosylase. The glycosylase first recognizes the damaged (or inappropriate) DNA base and then cleaves the N-C1 glycosidic bond between it and its deoxyribose sugar, generating a free base and an apyrimidinic (AP) site on the damaged strand of the DNA duplex (Lindahl and Wood 1999).
Literature References
PubMed ID Title Journal Year
10583946 Quality control by DNA repair

Lindahl, T, Wood, RD

Science 1999
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