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Base Excision Repair, AP site formation by depyrimidination
Stable Identifier
R-GGA-353234
Type
Pathway
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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DNA replication and repair (Gallus gallus)
DNA repair (Gallus gallus)
Base Excision Repair (Gallus gallus)
Base Excision Repair, AP site formation by depyrimidination (Gallus gallus)
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Base excision repair is initiated by DNA glycosylases that hydrolytically cleave the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base. Depyrimidination of a damaged nucleotide is mediated by a pyrimidine specific DNA glycosylase. The glycosylase first recognizes the damaged (or inappropriate) DNA base and then cleaves the N-C1 glycosidic bond between it and its deoxyribose sugar, generating a free base and an apyrimidinic (AP) site on the damaged strand of the DNA duplex (Lindahl and Wood 1999).
Literature References
PubMed ID
Title
Journal
Year
10583946
Quality control by DNA repair
Lindahl, T
,
Wood, RD
Science
1999
Participants
Events
Uracil glycosylase mediated recognition and binding of uracil opposite guanine
(Gallus gallus)
Cleavage of uracil by Uracil-glycosylase
(Gallus gallus)
TDG glycosylase mediated recognition and binding of thymine opposite guanine
(Gallus gallus)
Cleavage of thymine by TDG glycosylase
(Gallus gallus)
5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences
(Gallus gallus)
Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase
(Gallus gallus)
Participates
as an event of
Base Excision Repair (Gallus gallus)
Event Information
Go Biological Process
depyrimidination (0045008)
Authored
Saxena, A (2008-07-07)
Reviewed
Borowiec, JA (2009-04-24)
Created
Saxena, A (2008-06-12)
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