2-phosphoglycerate <=> phosphoenolpyruvate + H2O

Stable Identifier
R-GGA-353044
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Dehydration of 2-phosphoglycerate to form phosphoenolpyruvate
ReviewStatus
5/5
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2-phosphoglycerate <=> phosphoenolpyruvate + H2O
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Cytosolic enolase catalyzes the reversible magnesium-dependent dehydration of 2-phosphoglycerate to form phosphoenolpyruvate. The active form of the enzyme is a dimer. Three enolase isoforms have been isolated and biochemically characterized, 1 (alpha), 2 (gamma), and 3 (beta), as have 1:1, 1:2, 2:2, and 3:3 enolase dimers (Russell et al. 1986; Tanaka et al. 1985, 1995, 1998).

Literature References
PubMed ID Title Journal Year
9434147 cDNA cloning and characterization of neuron-specific enolase from chicken

Taniguchi, T, Nakashima, K, Tanaka, M, Ohkubo, T

Biochim Biophys Acta 1998
7629021 Chicken alpha-enolase but not beta-enolase has a Src-dependent tyrosine-phosphorylation site: cDNA cloning and nucleotide sequence analysis

Nakashima, K, Maeda, K, Tanaka, M

J Biochem 1995
3539098 The complete amino acid sequence of chicken skeletal-muscle enolase

Dunbar, B, Fothergill-Gilmore, LA, Russell, GA

Biochem J 1986
4093440 Purification, characterization, and distribution of enolase isozymes in chicken

Nakashima, K, Sugisaki, K, Tanaka, M

J Biochem 1985
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Catalyst Activity

phosphopyruvate hydratase activity of enolase dimer [cytosol]

Physical Entity
enolase dimer [cytosol] (Gallus gallus)
Activity
phosphopyruvate hydratase activity (GO:0004634)
This event is regulated
Requirements
Authored
D'Eustachio, P  (2008-09-10)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-09)
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