Cytosolic PGAM (phosphoglycerate mutase) catalyzes the reversible conversion of 2-phosphoglycerate to 3-phosphoglycerate. A protein with an amino acid sequence homologous to that of human PGAM has been identified in a high-thoughput analysis of chicken embryonic proteins (Agudo et al. 2005). Six additional proteins, PGAM1-like1, 2, and 3, PGAM2-like1 and 2, and PGAM5 are predicted to have phosphoglycerate mutase activity based on OrthoMCL analysis of the ENSEMBL chicken gene set.
phosphoglycerate mutase activity of PGAM [cytosol]